Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.52 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14381089 | 0.90 | CD274 (0.58) | CD274PDCD1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL4131157 | 0.84 | GAA (0.50) | GAAALDH1A1 | |
| SCHEMBL4109868 | 0.84 | FYN (0.50) | GAAALDH1A1RECQL | |
| SCHEMBL5202347 | 0.82 | GAA (0.47) | GAAKDM4ESMN1; SMN2 | |
| SCHEMBL5679827 | 0.82 | TUBB1 (0.45) | GAAALDH1A1 | |
| SCHEMBL5203311 | 0.80 | GAA (0.43) | CD274PDCD1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL13813556 | 0.79 | PTGS2 (0.53) | GAAALDH1A1 | |
| SCHEMBL7523189 | 0.79 | KMT2A (0.56) | CD274PDCD1GAAKDM4EPOLB | |
| SCHEMBL4120272 | 0.78 | GAA (0.46) | GAAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4122811 | 0.78 | LOXL2 (0.53) | GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400521-B1 | PIPERAZINE COMPOUNDS | KOWA CO (JP) | 2007-11-07 | — | — | EP | disclosed |
| CN-1309720-C | Piperazine compounds | KOWA CO (JP) | 2007-04-11 | — | — | CN | disclosed |
| CN-1520408-A | Piperazine compounds | ������������ʽ���� | 2004-08-11 | — | — | CN | disclosed |
| EP-1400521-A1 | PIPERAZINE COMPOUNDS | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6432957-B1 | ANTIASTHMA; ANTIALLERGENS; RHEUMATIC DISEASES; ANTIINFLAMMATORY AGENTS | KOWA CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |