Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201716 | 0.80 | CD274 (0.52) | GAAALDH1A1KDM4EGLAPDCD1 | |
| SCHEMBL4131157 | 0.77 | GAA (0.50) | GAAALDH1A1NPC1MAPTBRD4 | |
| SCHEMBL5200328 | 0.75 | HCRTR2 (0.35) | GAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5202347 | 0.74 | GAA (0.47) | GAAKDM4EBRD4SMN1; SMN2 | |
| SCHEMBL5202421 | 0.74 | EGFR (0.33) | GAAALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL13813556 | 0.73 | PTGS2 (0.53) | GAAALDH1A1NPC1MAPTBRD4 | |
| SCHEMBL5201979 | 0.72 | LOXL2 (0.33) | GAAALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5201228 | 0.72 | LOXL2 (0.33) | GAAALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL4109868 | 0.72 | FYN (0.50) | GAAALDH1A1NPC1MAPTBRD4 | |
| SCHEMBL4120272 | 0.72 | GAA (0.46) | GAAALDH1A1KDM4ENPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400521-B1 | PIPERAZINE COMPOUNDS | KOWA CO (JP) | 2007-11-07 | — | — | EP | disclosed |
| EP-1400521-A1 | PIPERAZINE COMPOUNDS | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6432957-B1 | ANTIASTHMA; ANTIALLERGENS; RHEUMATIC DISEASES; ANTIINFLAMMATORY AGENTS | KOWA CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |