Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | NEK2 | P51955 | 2/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14380785 | 0.85 | KCNH2 (0.40) | MEN1KMT2AHDAC1LOXL2 | |
| SCHEMBL5201716 | 0.82 | CD274 (0.52) | GAAKDM4ESMN1; SMN2 | |
| SCHEMBL4131157 | 0.82 | GAA (0.50) | GAABRD4 | |
| SCHEMBL4109868 | 0.79 | FYN (0.50) | GAAADORA3BRD4 | |
| SCHEMBL13813556 | 0.77 | PTGS2 (0.53) | GAAMEN1KMT2ABRD4 | |
| SCHEMBL5679901 | 0.76 | KMT2A (0.47) | KDM4EMEN1KMT2ANEK2 | |
| SCHEMBL4122811 | 0.76 | LOXL2 (0.53) | GAABRD4LOXL2 | |
| SCHEMBL4120272 | 0.76 | GAA (0.46) | GAAKDM4EBRD4 | |
| SCHEMBL6168415 | 0.76 | ALDH1A1 (0.55) | SMN1; SMN2 | |
| SCHEMBL5679827 | 0.74 | TUBB1 (0.45) | GAABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400521-B1 | PIPERAZINE COMPOUNDS | KOWA CO (JP) | 2007-11-07 | — | — | EP | disclosed |
| CN-1309720-C | Piperazine compounds | KOWA CO (JP) | 2007-04-11 | — | — | CN | disclosed |
| CN-1520408-A | Piperazine compounds | ������������ʽ���� | 2004-08-11 | — | — | CN | disclosed |
| EP-1400521-A1 | PIPERAZINE COMPOUNDS | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6432957-B1 | ANTIASTHMA; ANTIALLERGENS; RHEUMATIC DISEASES; ANTIINFLAMMATORY AGENTS | KOWA CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |