Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SMO | Q99835 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.42 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206068 | 0.85 | LMNA (0.49) | LMNAHTTSMOCNR2POLB | |
| SCHEMBL5203814 | 0.83 | SMO (0.51) | LMNAHTTSMOCNR2POLB | |
| SCHEMBL5205062 | 0.78 | SMO (0.46) | LMNAHTTSMOCNR2POLB | |
| SCHEMBL3598410 | 0.77 | SMO (0.54) | LMNAHTTSMOCNR2POLB | |
| SCHEMBL5203146 | 0.76 | SMO (0.47) | LMNAHTTSMOCNR2POLB | |
| SCHEMBL5203143 | 0.73 | CNR2 (0.43) | LMNAHTTSMOCNR2POLB | |
| SCHEMBL4862005 | 0.73 | SLC5A1 (0.51) | LMNAHDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL13445248 | 0.72 | SMO (0.57) | SMOCNR2NPSR1HRH2SLC5A1 | |
| SCHEMBL20431374 | 0.71 | SMO (0.54) | LMNAHTTSMOCNR2POLB | |
| SCHEMBL3599338 | 0.71 | SLC2A1 (0.55) | SMOCNR2NPSR1HRH2SLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |