Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.60 |
| ▸ | CA2 | P00918 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | UQCRB | P14927 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | RORA | P35398 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046801 | 0.85 | FFAR1 (0.51) | CA1CA2HTTMEN1MAPT | |
| SCHEMBL3332937 | 0.83 | CA12 (0.65) | CA1CA2ALDH1A1POLBHTT | |
| SCHEMBL12042475 | 0.81 | ALDH1A1 (0.71) | CA1CA2ALDH1A1UQCRBSMN1; SMN2 | |
| SCHEMBL965226 | 0.81 | KEAP1 (0.66) | CA1CA2ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL5041834 | 0.80 | MEN1 (0.55) | CA1CA2ALDH1A1POLBMEN1 | |
| SCHEMBL28821888 | 0.80 | UQCRB (0.54) | CA1CA2ALDH1A1UQCRBSMN1; SMN2 | |
| SCHEMBL5046841 | 0.80 | HSD17B2 (0.55) | CA1CA2ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL751419 | 0.80 | CYP19A1 (0.63) | ALDH1A1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL10774342 | 0.80 | KMT2A (0.65) | CA1CA2ALDH1A1HTTMEN1 | |
| SCHEMBL5040134 | 0.79 | ALDH1A1 (0.50) | CA1CA2ALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802572-A1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006032541-A1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-03-30 | — | — | WO | disclosed |