SCHEMBL5202269

SCHEMBL5202269

CC(C)(C)OC(=O)NCc1cccc(Oc2cc(Cl)ccc2N(Cc2ccc(Cl)c(Cl)c2)C(=O)CCC(=O)NCc2ccccc2F)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
KDM4E B2RXH2 1/20 0.39
HTT P42858 2/20 0.37
NPSR1 Q6W5P4 2/20 0.37
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.37
SMN1; SMN2 Q16637 4/20 0.36
AHCY P23526 1/20 0.36
TRPV1 Q8NER1 1/20 0.36
TSPO P30536 1/20 0.36
MAPK1 P28482 1/20 0.35
P2RX4 Q99571 1/20 0.35
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
PPARG P37231 1/20 0.34
PPARD Q03181 1/20 0.34
PPARA Q07869 1/20 0.34
TSHR P16473 2/20 0.34
ANO1 Q5XXA6 1/20 0.34
HCRTR2 O43614 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5204994 0.93 ALDH1A1 (0.40) ALDH1A1KDM4EHTTNPSR1LMNA
SCHEMBL5203418 0.92 ALDH1A1 (0.40) ALDH1A1KDM4EHTTNPSR1LMNA
SCHEMBL5208124 0.88 PPARG (0.40) SMN1; SMN2TRPV1TSPOPPARGPPARD
Hydrochloric Acid SCHEMBL5208231 0.87 AHCY (0.39) ALDH1A1KDM4EHTTNPSR1LMNA
SCHEMBL5204960 0.86 HTT (0.37) ALDH1A1KDM4EHTTNPSR1LMNA
SCHEMBL5201664 0.86 TSHR (0.43) SMN1; SMN2TSPOPPARGPPARDPPARA
SCHEMBL5206214 0.84 ALDH1A1 (0.40) ALDH1A1KDM4EHTTNPSR1LMNA
SCHEMBL5204311 0.84 ALDH1A1 (0.42) ALDH1A1KDM4EHTTNPSR1LMNA
SCHEMBL5205381 0.81 HDAC1 (0.41) TSPOPPARGPPARDPPARA
SCHEMBL5202464 0.80 ALDH1A1 (0.41) ALDH1A1KDM4EHTTNPSR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7160887-B1 Aromatic amine derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-09 US disclosed
EP-1123918-B1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME TAKEDA PHARMACEUTICAL (JP) 2005-03-09 EP disclosed
EP-1123918-A1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME Takeda Chemical Industries, Ltd. (JP) 2001-08-16 EP disclosed