SCHEMBL5204960

SCHEMBL5204960

CC(C)(C)OC(=O)NCCc1cccc(Oc2cc(Cl)ccc2N(Cc2ccc(-c3ccccc3)cc2)C(=O)CCC(=O)NCc2ccccc2F)c1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HTT P42858 3/20 0.37
NPSR1 Q6W5P4 3/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
NR3C1 P04150 2/20 0.37
AHCY P23526 1/20 0.37
TSPO P30536 1/20 0.36
ALDH1A1 P00352 4/20 0.36
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
KDM4E B2RXH2 2/20 0.35
MAPT P10636 2/20 0.35
GAA P10253 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MAPK1 P28482 1/20 0.34
SUCNR1 Q9BXA5 1/20 0.34
P2RX4 Q99571 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5203418 0.94 ALDH1A1 (0.40) HTTNPSR1L3MBTL1AHCYTSPO
SCHEMBL5208677 0.89 NR3C1 (0.41) NR3C1TSPOALDH1A1LMNAKDM4E
SCHEMBL5204994 0.88 ALDH1A1 (0.40) HTTNPSR1L3MBTL1AHCYTSPO
Hydrochloric Acid SCHEMBL5206604 0.88 AHCY (0.38) HTTNPSR1L3MBTL1NR3C1AHCY
SCHEMBL5206214 0.87 ALDH1A1 (0.40) HTTNPSR1L3MBTL1ALDH1A1LMNA
SCHEMBL5204311 0.86 ALDH1A1 (0.42) HTTNPSR1L3MBTL1TSPOALDH1A1
SCHEMBL5202269 0.86 ALDH1A1 (0.39) HTTNPSR1L3MBTL1AHCYTSPO
Hydrochloric Acid SCHEMBL5208410 0.86 SSTR5 (0.42) HTTNPSR1L3MBTL1AHCYTSPO
SCHEMBL5205381 0.83 HDAC1 (0.41) TSPOSUCNR1
SCHEMBL5202464 0.82 ALDH1A1 (0.41) HTTNPSR1L3MBTL1NR3C1TSPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7160887-B1 Aromatic amine derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-09 US disclosed
EP-1123918-B1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME TAKEDA PHARMACEUTICAL (JP) 2005-03-09 EP disclosed
EP-1123918-A1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME Takeda Chemical Industries, Ltd. (JP) 2001-08-16 EP disclosed