Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 2/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17255057 | 0.81 | MEN1 (0.34) | NFE2L2ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL31028560 | 0.81 | MEN1 (0.34) | NFE2L2ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL29954958 | 0.79 | NOS3 (0.36) | NFE2L2KIF11ERN1TSHRHSD17B10 | |
| SCHEMBL27979595 | 0.79 | NOS3 (0.36) | NFE2L2KIF11ERN1TSHRHSD17B10 | |
| SCHEMBL31711438 | 0.77 | NFE2L2 (0.35) | NFE2L2KIF11 | |
| SCHEMBL4383164 | 0.76 | SORT1 (0.33) | SORT1ALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL29953139 | 0.75 | ERN1 (0.35) | ALDH1A1KDM4EMEN1LMNAHPGD | |
| SCHEMBL30547062 | 0.75 | DHODH (0.35) | SORT1ALDH1A1SLC22A12CYP1A2CYP3A4 | |
| SCHEMBL4383170 | 0.75 | DHODH (0.35) | SORT1ALDH1A1SLC22A12CYP1A2CYP3A4 | |
| SCHEMBL15147449 | 0.74 | CYP1A2 (0.37) | SORT1ALDH1A1SLC22A12CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |