Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.36 |
| ▸ | NOS2 | P35228 | 3/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29954958 | 1.00 | NOS3 (0.36) | NOS3NOS2TLR7RPS6KB1AKT1 | |
| SCHEMBL3159490 | 0.81 | NOS3 (0.36) | NOS3NOS2GLAPOLBGAA | |
| SCHEMBL5202743 | 0.79 | SORT1 (0.35) | HSD17B10KIF11NFE2L2ERN1TSHR | |
| SCHEMBL17255057 | 0.79 | MEN1 (0.34) | KIF11NFE2L2ERN1POLB | |
| SCHEMBL31028560 | 0.79 | MEN1 (0.34) | KIF11NFE2L2ERN1POLB | |
| SCHEMBL31711438 | 0.75 | NFE2L2 (0.35) | KIF11NFE2L2 | |
| SCHEMBL16856841 | 0.75 | MAPT (0.42) | HSD17B10HRH4GLAGAATSHR | |
| SCHEMBL27227418 | 0.75 | ALDH1A1 (0.37) | NOS3NOS2HTTERN1 | |
| SCHEMBL29435659 | 0.74 | NOS3 (0.46) | NOS3NOS2TLR7HTTHSD17B10 | |
| SCHEMBL8131114 | 0.74 | NOS2 (0.37) | NOS3NOS2ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102143957-B | Benzimidazoles and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2014-08-20 | — | — | CN | disclosed |