Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.48 |
| ▸ | GSK3B | P49841 | 4/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.48 |
| ▸ | AKT1 | P31749 | 3/20 | 0.48 |
| ▸ | NEK4 | P51957 | 3/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.48 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.48 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.48 |
| ▸ | GSK3A | P49840 | 3/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717471 | 0.86 | MEN1 (0.61) | KDM4EGAAITGB3ITGA2BMEN1 | |
| SCHEMBL5027698 | 0.86 | MEN1 (0.61) | KDM4EGAAITGB3ITGA2BMEN1 | |
| SCHEMBL22995641 | 0.86 | MEN1 (0.61) | KDM4EGAAITGB3ITGA2BMEN1 | |
| SCHEMBL9830762 | 0.82 | KDM4E (0.55) | KDM4EGAAITGB3ITGA2BMEN1 | |
| SCHEMBL29157147 | 0.82 | LMNA (0.58) | KDM4EGAAMEN1KMT2AROCK1 | |
| SCHEMBL7822835 | 0.79 | KDM4E (0.67) | KDM4EGAAITGB3ITGA2BCTSA | |
| SCHEMBL17313721 | 0.79 | KDM4E (0.51) | KDM4EGAAITGB3ITGA2BMEN1 | |
| SCHEMBL3995786 | 0.79 | TAOK1 (0.59) | ROCK1GSK3BCLK4ROCK2RPS6KA5 | |
| SCHEMBL2850903 | 0.78 | NPC1 (0.57) | KDM4EGAAITGB3MEN1KMT2A | |
| SCHEMBL27761114 | 0.78 | CTSA (0.62) | ROCK1GSK3BCLK4ROCK2RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135374-B9 | BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1135374-B1 | BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2006-09-06 | — | — | EP | disclosed |
| EP-1135374-A1 | BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2001-09-26 | — | — | EP | disclosed |
| US-6204282-B1 | TREATING CANCER, RETINOPATHY, ATHEROSCLEROSIS, VASCULAR RESTENOSIS, OR OSTEOPOROSIS. | SCHERING CORPORATION | 2001-03-20 | — | — | US | disclosed |
| WO-2000032578-A1 | BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2000-06-08 | — | — | WO | disclosed |