Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207653 | 0.89 | POLB (0.38) | NPC1RAB9ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL5202529 | 0.85 | MET (0.41) | SLC22A12SLC6A2SLC6A3SCN9AMET | |
| SCHEMBL5206507 | 0.81 | SLC6A2 (0.39) | NPC1RAB9ASLC6A2SLC6A3SCN9A | |
| SCHEMBL5207523 | 0.79 | CCNC (0.39) | SCN9A | |
| SCHEMBL5206090 | 0.76 | BCL6 (0.42) | SLC22A12SLC6A2SLC6A3SCN9ASLC6A4 | |
| SCHEMBL7161086 | 0.75 | MAPK14 (0.43) | NPC1RAB9AFLT3 | |
| SCHEMBL7161091 | 0.75 | MAPK14 (0.43) | NPC1RAB9AFLT3 | |
| SCHEMBL5207644 | 0.75 | MAPT (0.35) | NPC1RAB9ASCN9AMET | |
| SCHEMBL5206305 | 0.75 | MAPT (0.33) | NPC1RAB9A | |
| SCHEMBL5206436 | 0.72 | MAPT (0.38) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |