Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | STK17B | O94768 | 2/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203455 | 0.88 | TTR (0.40) | BCL6SLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL5207181 | 0.84 | BCL6 (0.40) | BCL6SLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL5207953 | 0.80 | SLC6A2 (0.44) | SLC6A2SLC6A3SLC6A4CYP2C19ALDH1A1 | |
| SCHEMBL7513223 | 0.77 | CCNT1 (0.37) | BCL6CYP2D6CYP2C19STK17BSTK17A | |
| SCHEMBL5205013 | 0.77 | KCNH2 (0.40) | CYP2D6CYP2C19STK17ACCNT1ALDH1A1 | |
| SCHEMBL7161091 | 0.76 | MAPK14 (0.43) | CCNT1 | |
| SCHEMBL7161086 | 0.76 | MAPK14 (0.43) | CCNT1 | |
| SCHEMBL5203877 | 0.76 | NPC1 (0.36) | SLC6A2SLC6A3SLC6A4SLC22A12SCN9A | |
| SCHEMBL7716686 | 0.72 | HTR3E (0.42) | SLC6A4MAPTSCN9A | |
| SCHEMBL5205294 | 0.72 | MMP13 (0.40) | ALDH1A1MAPTSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |