Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.33 |
| ▸ | RELA | Q04206 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6339071 | 0.81 | CLK1 (0.36) | CYP3A4USP2MAPK1SMN1; SMN2ABCG2 | |
| SCHEMBL5205321 | 0.77 | CLK1 (0.38) | CYP3A4USP2MAPK1SMN1; SMN2ABCG2 | |
| SCHEMBL5203369 | 0.73 | MEN1 (0.33) | CYP3A4USP2MAPK1SMN1; SMN2KMT2A | |
| SCHEMBL5208618 | 0.72 | USP2 (0.38) | CYP3A4USP2MAPK1SMN1; SMN2ABCG2 | |
| SCHEMBL18131710 | 0.70 | NFE2L2 (0.39) | CYP3A4MAPK1SMN1; SMN2CLK1DYRK1A | |
| SCHEMBL5207796 | 0.70 | CYP3A4 (0.52) | CYP3A4KMT2AMAPTMEN1 | |
| SCHEMBL6628469 | 0.70 | RXFP1 (0.39) | CYP3A4USP2MAPK1SMN1; SMN2KMT2A | |
| SCHEMBL28905844 | 0.69 | BRD9 (0.46) | KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL5206460 | 0.69 | CA12 (0.35) | CYP3A4USP2MAPK1SMN1; SMN2KMT2A | |
| SCHEMBL5206042 | 0.69 | CA12 (0.35) | CYP3A4USP2MAPK1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1403251-B1 | BIS(2-ARYL-5-PYRIDYL) DERIVATIVE | KOWA CO (JP) | 2007-07-18 | — | — | EP | disclosed |
| EP-1403251-A1 | BIS(2-ARYL-5-PYRIDYL) DERIVATIVE | Kowa Co., Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |