Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 6/20 | 0.57 |
| ▸ | HTR6 | P50406 | 4/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784884 | 0.93 | DRD2 (0.57) | DRD2HTR1AHTR6KCNH2 | |
| SCHEMBL7787397 | 0.91 | HTR1A (0.59) | DRD2HTR1A | |
| SCHEMBL5201914 | 0.89 | HTR1A (0.63) | HTR1AKCNH2 | |
| SCHEMBL5201581 | 0.87 | HTR1A (0.63) | DRD2HTR1AHTR6KCNH2 | |
| SCHEMBL7788871 | 0.87 | HTR1A (0.65) | DRD2HTR1A | |
| SCHEMBL5203078 | 0.87 | KDM4E (0.56) | — | |
| SCHEMBL7787590 | 0.85 | HTR1A (0.54) | DRD2HTR1AKCNH2 | |
| SCHEMBL5203306 | 0.85 | HTR1A (0.50) | HTR1A | |
| SCHEMBL5203086 | 0.85 | HTR1A (0.51) | DRD2HTR1A | |
| SCHEMBL7787588 | 0.84 | SLC6A4 (0.56) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998474-B1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-07 | — | — | EP | disclosed |
| US-6251908-B1 | Piperazine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2001-06-26 | — | — | US | disclosed |