Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 7/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203900 | 0.93 | DRD2 (0.57) | DRD2HTR6KCNH2HTR1A | |
| SCHEMBL7787397 | 0.91 | HTR1A (0.59) | DRD2HTR1A | |
| SCHEMBL7787379 | 0.89 | DRD2 (0.57) | DRD2SLC6A4HTR7KCNH2HTR1A | |
| SCHEMBL7788889 | 0.87 | HTR1A (0.57) | DRD2HTR1A | |
| SCHEMBL7787373 | 0.87 | KDM4E (0.47) | DRD2HTR1A | |
| SCHEMBL7784886 | 0.87 | HTR1A (0.55) | DRD2HTR6KCNH2HTR1A | |
| SCHEMBL7780263 | 0.85 | DRD2 (0.49) | DRD2SLC6A4HTR6KCNH2HTR1A | |
| SCHEMBL7787574 | 0.85 | HTR1A (0.48) | DRD2SLC6A4HTR7KCNH2HTR1A | |
| SCHEMBL8131459 | 0.85 | DRD2 (0.46) | DRD2HTR1A | |
| SCHEMBL7785380 | 0.84 | SLC6A4 (0.49) | SLC6A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251908-B1 | Piperazine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2001-06-26 | — | — | US | disclosed |