Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827168 | 0.90 | TYR (0.43) | TYR | |
| SCHEMBL5202082 | 0.85 | TYR (0.47) | TYRLMNAACHEGUSB | |
| SCHEMBL2331746 | 0.84 | TYR (0.39) | TYRLMNASLC5A1SLC5A2 | |
| SCHEMBL3958574 | 0.84 | TYR (0.39) | TYRLMNASLC5A1SLC5A2 | |
| SCHEMBL4686426 | 0.83 | TYR (0.57) | TYR | |
| SCHEMBL3955351 | 0.83 | MEN1 (0.51) | TYRLMNAACHESLC5A1SLC5A2 | |
| SCHEMBL7723547 | 0.82 | TYR (0.40) | TYRLMNAADRA1AACHE | |
| SCHEMBL26999415 | 0.81 | ACHE (0.54) | LMNACHRM1SLC6A2ADRA1AACHE | |
| SCHEMBL14125895 | 0.80 | GABRA1 (0.42) | LMNACHRM1ADRA1AACHE | |
| SCHEMBL14855983 | 0.79 | TYR (0.47) | TYRLMNAADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802599-A2 | HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS | The Ohio State University Research Foundation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2007001348-A2 | HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2007-01-04 | — | — | WO | disclosed |