Sugi Predict

Sugi Predict / Compounds / SCHEMBL5204231

SCHEMBL5204231

SCHEMBL5204231

COC(=O)c1cc2c(C=S)c[nH]c2cc1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR4A2 P43354 10/20 0.50
▸ CREBBP Q92793 1/20 0.41
▸ PRKAG1 P54619 5/20 0.38
▸ PRKAA1 Q13131 5/20 0.38
▸ PRKAB1 Q9Y478 5/20 0.38
▸ PRKAB2 O43741 4/20 0.38
▸ PRKAA2 P54646 4/20 0.38
▸ PRKAG3 Q9UGI9 4/20 0.38
▸ PRKAG2 Q9UGJ0 4/20 0.38
▸ MTNR1A P48039 3/20 0.37
▸ MTNR1B P49286 3/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ CYP2D6 P10635 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ NFKB1 P19838 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ SLC6A4 P31645 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9106007 0.79 NR4A2 (0.57) NR4A2CREBBPPRKAG1PRKAA1PRKAB1
SCHEMBL14350625 0.77 NR4A2 (0.51) NR4A2CREBBPPRKAG1PRKAA1PRKAB1
SCHEMBL5204235 0.76 NR4A2 (0.50) NR4A2CREBBPPRKAG1PRKAA1PRKAB1
SCHEMBL5378634 0.71 LMNA (0.40) PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2
SCHEMBL15300951 0.70 NR4A2 (0.61) NR4A2CREBBPPRKAG1PRKAA1PRKAB1
SCHEMBL70011 0.70 GAA (0.58) NR4A2MEN1LMNAKMT2AMAPT
SCHEMBL29085148 0.69 ALDH1A1 (0.47) NR4A2CREBBPMTNR1AMTNR1BCYP1A2
SCHEMBL71501 0.68 GAA (0.52) NR4A2MEN1LMNAKMT2AMAPT
SCHEMBL10478188 0.68 NR4A2 (0.53) NR4A2CREBBPPRKAG1PRKAA1PRKAB1
SCHEMBL11693692 0.67 GAA (0.45) NR4A2MEN1LMNAKMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7304048-B2 Indole-type derivatives as inhibitors of p38 kinase SCIOS, INC. (US) 2007-12-04 — — US disclosed
US-7291613-B2 Inhibitors of p38 kinase SCIOS, INC. (US) 2007-11-06 — — US disclosed
EP-1178983-B1 INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE SCIOS INC (US) 2007-10-24 — — EP disclosed
US-20070161649-A1 INDOLE-TYPE DERIVATIVES AS INHIBITORS OF p38 KINASE SCIOS INC. 2007-07-12 — — US disclosed
US-7238712-B2 Indole-type derivatives as inhibitors of p38 kinase SCIOS, INC. (US) 2007-07-03 — — US disclosed
US-7189726-B2 Benzofuran derivatives as inhibitors of p38-α kinase SCIOS, INC. (US) 2007-03-13 — — US disclosed
US-20050171183-A1 Indole-type inhibitors of p38 kinase SCIOS, INC. (US) 2005-08-04 — — US disclosed
US-20050130965-A1 Inhibitors of p38 kinase SCIOS, INC. 2005-06-16 — — US disclosed
US-6890938-B2 Indole-type inhibitors of p38 kinase SCIOS, INC. (US) 2005-05-10 — — US disclosed
US-6867209-B1 Indole-type derivatives as inhibitors of p38 kinase SCIOS, INC. (US) 2005-03-15 — — US disclosed
EP-1339708-A2 INDOLE-TYPE INHIBITORS OF P38 KINASE Scios Inc. (US) 2003-09-03 — — EP disclosed
US-20030162970-A1 Indole-type derivatives as inhibitors of p38 kinase SCIOS, INC. 2003-08-28 — — US disclosed
US-20030158417-A1 Benzofuran derivatives as inhibitors of p38-alpha kinase SCIOS, INC. 2003-08-21 — — US disclosed
US-20030144520-A1 Indole-type derivatives as inhibitors of p38 kinase MAVUNKEL BABU J (US) 2003-07-31 — — US disclosed
US-20030100588-A1 Indole-type inhibitors of p38 kinase SCIOS, INC. 2003-05-29 — — US disclosed
US-20030092717-A1 Inhibitors of p38 kinase SCIOS, INC. 2003-05-15 — — US disclosed
WO-2002044168-A2 INDOLE-TYPE INHIBITORS OF P38 KINASE SCIOS INC. (US) 2002-06-06 — — WO disclosed
WO-2002042292-A2 INDOL DERIVATIVE AND THEIR USE AS INHIBITORS OF P38 KINASE SCIOS INC. (US) 2002-05-30 — — WO disclosed
EP-1178983-A1 INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE Scios Inc. (US) 2002-02-13 — — EP disclosed
WO-2000071535-A1 INDOLE-TYPE DERIVATIVES AS INHIBITORS OF p38 KINASE SCIOS INC. (US) 2000-11-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050130965-A1 Inhibitors of p38 kinase MAPK1, MAPKAPK2, MAP3K1 NR4A2 3346/4885CREBBP 1679/4885PRKAG1 311/4885
US-20070161649-A1 INDOLE-TYPE DERIVATIVES AS INHIBITORS OF p38 KINASE GRK6, CSNK2A2, CSNK2A1 NR4A2 302/4885CREBBP 2520/4885PRKAG1 1517/4885
US-20030144520-A1 Indole-type derivatives as inhibitors of p38 kinase CNKSR1, MAPK1, CSNK1A1 NR4A2 770/4885CREBBP 3096/4885PRKAG1 1515/4885
US-20030100588-A1 Indole-type inhibitors of p38 kinase CNKSR1, MAPK1, MAP2K6 NR4A2 862/4885CREBBP 3444/4885PRKAG1 1508/4885
US-20030092717-A1 Inhibitors of p38 kinase MAPK1, CNKSR1, MOK NR4A2 699/4885CREBBP 2537/4885PRKAG1 1046/4885
US-20030158417-A1 Benzofuran derivatives as inhibitors of p38-alpha kinase CNKSR1, CSNK2A1, CSNK1A1 NR4A2 268/4885CREBBP 1536/4885PRKAG1 1781/4885
US-20030162970-A1 Indole-type derivatives as inhibitors of p38 kinase CNKSR1, MAPK1, CSNK1A1 NR4A2 770/4885CREBBP 3096/4885PRKAG1 1515/4885
US-20050171183-A1 Indole-type inhibitors of p38 kinase MAPK1, MAPKAPK2, MAP3K1 NR4A2 1829/4885CREBBP 904/4885PRKAG1 466/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.