Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 7/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 7/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 7/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 7/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 7/20 | 0.35 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378636 | 0.77 | LMNA (0.49) | LMNATSHRALDH1A1CYP2C9NFKB1 | |
| SCHEMBL5915286 | 0.74 | ALDH1A1 (0.59) | LMNATSHRALDH1A1CYP2C9NFKB1 | |
| SCHEMBL5387155 | 0.73 | ALDH1A1 (0.44) | LMNATSHRALDH1A1CYP2C9NFKB1 | |
| SCHEMBL5204231 | 0.71 | NR4A2 (0.50) | LMNACYP2C9NFKB1PRKAB2PRKAG1 | |
| SCHEMBL8800942 | 0.70 | CSNK2A1 (0.58) | LMNATSHRALDH1A1CYP2C9NFKB1 | |
| SCHEMBL27033587 | 0.70 | TSHR (0.49) | LMNATSHRALDH1A1CYP2C9NFKB1 | |
| SCHEMBL27569328 | 0.69 | ALDH1A1 (0.52) | LMNATSHRALDH1A1CYP2C9NFKB1 | |
| SCHEMBL840736 | 0.66 | GPR84 (0.65) | LMNATSHRALDH1A1CYP2C9NFKB1 | |
| SCHEMBL29623480 | 0.66 | GPR84 (0.65) | LMNATSHRALDH1A1CYP2C9NFKB1 | |
| SCHEMBL4837065 | 0.66 | AKR1B1 (0.45) | CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189739-B2 | Compounds and methods to treat cardiac failure and other disorders | SCIOS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | disclosed |
| US-6589954-B1 | Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful | SCIOS, INC. | 2003-07-08 | — | — | US | disclosed |
| US-6340685-B1 | ANTIINFLAMMATORY AGENTS | SCIOS, INC. | 2002-01-22 | — | — | US | disclosed |
| EP-1080078-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061426-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 1999-12-02 | — | — | WO | disclosed |