Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206812 | 0.89 | SIGMAR1 (0.40) | OPRM1HTR2ASIGMAR1CCR3CACNA1G | |
| SCHEMBL5204772 | 0.89 | KCNH2 (0.41) | OPRM1SIGMAR1KDM1AKCNH2 | |
| SCHEMBL5201930 | 0.87 | HTR2A (0.47) | OPRM1HTR2AHTR2C | |
| SCHEMBL5207344 | 0.85 | CACNA1G (0.49) | OPRM1HTR2ASIGMAR1CACNA1GHTR2C | |
| SCHEMBL5204477 | 0.83 | KCNH2 (0.42) | OPRM1HTR2ASIGMAR1DRD2KCNH2 | |
| SCHEMBL5204028 | 0.81 | SIGMAR1 (0.42) | OPRM1SIGMAR1CACNA1GDRD2KCNH2 | |
| SCHEMBL5206815 | 0.79 | SLC22A12 (0.44) | OPRM1SIGMAR1DRD2KCNH2 | |
| SCHEMBL5204303 | 0.78 | KDM4E (0.36) | SIGMAR1PTGDR2KDM4EALDH1A1HPGD | |
| SCHEMBL5871576 | 0.77 | MCHR1 (0.42) | OPRM1SIGMAR1CCR3CACNA1GHRH1 | |
| SCHEMBL5204779 | 0.75 | AKR1B1 (0.38) | OPRM1SIGMAR1DRD2OPRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1179532-B1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | EISAI R&D MAN CO LTD (JP) | 2007-06-13 | — | — | EP | disclosed |
| US-6573384-B1 | 1,4-substituted cyclic amine compound which is useful as a pharmaceutical, and an intermediate for the process | EISAI CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-1179532-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | Eisai Co., Ltd. (JP) | 2002-02-13 | — | — | EP | disclosed |