Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | PLD2 | O14939 | 1/20 | 0.38 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | EBP | Q15125 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204028 | 0.91 | SIGMAR1 (0.42) | KCNH2OPRM1SLC6A4HTR1ADRD2 | |
| SCHEMBL5201930 | 0.90 | HTR2A (0.47) | OPRM1HTR2A | |
| SCHEMBL5201956 | 0.90 | KCNH2 (0.43) | KCNH2L3MBTL1OPRM1SLC6A4HTR1A | |
| SCHEMBL5204772 | 0.87 | KCNH2 (0.41) | KCNH2OPRM1SLC6A4HTR1ASIGMAR1 | |
| SCHEMBL5207344 | 0.85 | CACNA1G (0.49) | OPRM1HTR2ASIGMAR1 | |
| SCHEMBL5204295 | 0.83 | OPRM1 (0.40) | KCNH2OPRM1DRD2HTR2ASIGMAR1 | |
| SCHEMBL5205196 | 0.82 | HTR2A (0.47) | OPRM1HTR2A | |
| SCHEMBL5206848 | 0.80 | SIGMAR1 (0.44) | KCNH2OPRM1SLC6A4HTR1ADRD2 | |
| SCHEMBL5204747 | 0.77 | CACNA1G (0.49) | OPRM1HTR2ASIGMAR1 | |
| SCHEMBL5206815 | 0.77 | SLC22A12 (0.44) | KCNH2OPRM1DRD2SIGMAR1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1179532-B1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | EISAI R&D MAN CO LTD (JP) | 2007-06-13 | — | — | EP | disclosed |
| US-6573384-B1 | 1,4-substituted cyclic amine compound which is useful as a pharmaceutical, and an intermediate for the process | EISAI CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-1179532-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | Eisai Co., Ltd. (JP) | 2002-02-13 | — | — | EP | disclosed |