Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206848 | 0.91 | SIGMAR1 (0.44) | SIGMAR1OPRM1HTR1ASLC6A4CCR5 | |
| SCHEMBL5204477 | 0.91 | KCNH2 (0.42) | SIGMAR1OPRM1HTR1ASLC6A4DRD2 | |
| SCHEMBL5207344 | 0.89 | CACNA1G (0.49) | SIGMAR1OPRM1CCR5CACNA1GCACNA1H | |
| SCHEMBL5204772 | 0.85 | KCNH2 (0.41) | SIGMAR1OPRM1HTR1ASLC6A4DRD4 | |
| SCHEMBL5201930 | 0.85 | HTR2A (0.47) | OPRM1 | |
| SCHEMBL5204295 | 0.81 | OPRM1 (0.40) | SIGMAR1OPRM1CCR5DRD2KCNH2 | |
| SCHEMBL5204747 | 0.81 | CACNA1G (0.49) | SIGMAR1OPRM1CCR5CACNA1GCACNA1H | |
| SCHEMBL5201956 | 0.81 | KCNH2 (0.43) | SIGMAR1OPRM1HTR1ASLC6A4DRD2 | |
| SCHEMBL5205196 | 0.77 | HTR2A (0.47) | OPRM1 | |
| SCHEMBL5204779 | 0.77 | AKR1B1 (0.38) | SIGMAR1OPRM1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1179532-B1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | EISAI R&D MAN CO LTD (JP) | 2007-06-13 | — | — | EP | disclosed |
| US-6573384-B1 | 1,4-substituted cyclic amine compound which is useful as a pharmaceutical, and an intermediate for the process | EISAI CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-1179532-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | Eisai Co., Ltd. (JP) | 2002-02-13 | — | — | EP | disclosed |