Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL5204380

CC(C)(C)c1ccc(CN(C(=O)CCC(=O)NCc2ccccc2C(F)(F)F)c2ccccc2Oc2cccc(CN)c2)cc1.O=C(O)C(F)(F)F

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 8/20 0.38
HDAC11 Q96DB2 2/20 0.37
HDAC6 Q9UBN7 2/20 0.37
PPARG P37231 8/20 0.37
TPSAB1 Q15661 2/20 0.37
PPARD Q03181 2/20 0.36
PPARA Q07869 2/20 0.36
P2RX4 Q99571 1/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HTT P42858 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
TSPO P30536 1/20 0.36
TAOK1 Q7L7X3 1/20 0.36
TAOK3 Q9H2K8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL5202498 0.94 EPHX2 (0.38) EPHX2PPARGTPSAB1P2RX4KDM4E
Trifluoroacetic Acid SCHEMBL5203166 0.94 ALDH1A1 (0.39) HDAC11HDAC6PPARGTPSAB1PPARD
Trifluoroacetic Acid SCHEMBL5202054 0.93 TSPO (0.39) EPHX2PPARGTPSAB1TSPO
Trifluoroacetic Acid SCHEMBL5202242 0.92 TPSAB1 (0.37) PPARGTPSAB1PPARDPPARATSPO
Trifluoroacetic Acid SCHEMBL5202835 0.91 TPSAB1 (0.36) PPARGTPSAB1PPARDPPARAKDM4E
Trifluoroacetic Acid SCHEMBL5206020 0.91 ALDH1A1 (0.43) EPHX2HDAC6TPSAB1ALDH1A1TSPO
Trifluoroacetic Acid SCHEMBL5205650 0.91 TAOK1 (0.38) EPHX2PPARGTPSAB1P2RX4KDM4E
Trifluoroacetic Acid SCHEMBL5205396 0.90 TSPO (0.41) EPHX2KDM4EALDH1A1HTTTDP1
Trifluoroacetic Acid SCHEMBL5205693 0.90 CSF1R (0.39) EPHX2TPSAB1P2RX4KDM4EALDH1A1
Trifluoroacetic Acid SCHEMBL5203361 0.90 TPSAB1 (0.38) HDAC11HDAC6PPARGTPSAB1PPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7160887-B1 Aromatic amine derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-09 US disclosed
EP-1123918-B1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME TAKEDA PHARMACEUTICAL (JP) 2005-03-09 EP disclosed
EP-1123918-A1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME Takeda Chemical Industries, Ltd. (JP) 2001-08-16 EP disclosed