SCHEMBL5204433

SCHEMBL5204433

O=C1CCc2cc(C(=O)O)ccc2C2=C1CCC2

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 5/20 0.55
SRD5A1 P18405 4/20 0.55
ALDH1A1 P00352 2/20 0.53
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
PRKCI P41743 1/20 0.42
KDM4E B2RXH2 1/20 0.42
MAPT P10636 1/20 0.42
CASP1 P29466 1/20 0.41
CASP7 P55210 1/20 0.41
HSD17B10 Q99714 1/20 0.41
HSD17B1 P14061 2/20 0.41
TTR P02766 1/20 0.40
BAZ2B Q9UIF8 1/20 0.39
GAA P10253 1/20 0.39
PTPRC P08575 2/20 0.39
GRM5 P41594 1/20 0.39
MITF O75030 1/20 0.38
HSP90AA1 P07900 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29431442 0.87 SRD5A2 (0.66) SRD5A2SRD5A1ALDH1A1MAOAMAOB
SCHEMBL1275273 0.87 SRD5A2 (0.66) SRD5A2SRD5A1ALDH1A1MAOAMAOB
SCHEMBL356493 0.83 ALDH1A1 (0.65) SRD5A2SRD5A1ALDH1A1MAOAMAOB
SCHEMBL29546005 0.83 ALDH1A1 (0.65) SRD5A2SRD5A1ALDH1A1MAOAMAOB
SCHEMBL7716113 0.82 PTPRC (0.46) SRD5A2SRD5A1ALDH1A1MAOAMAOB
SCHEMBL1091562 0.80 ALDH1A1 (0.59) SRD5A2SRD5A1ALDH1A1MAOAMAOB
SCHEMBL1845264 0.79 SRD5A2 (0.81) SRD5A2SRD5A1ALDH1A1KDM4EMAPT
SCHEMBL5203864 0.79 MAOB (0.69) MAOAMAOBPRKCICASP1CASP7
SCHEMBL8253251 0.78 SRD5A2 (0.68) SRD5A2SRD5A1ALDH1A1KDM4EMAPT
Hydrochloric Acid SCHEMBL11806873 0.77 SRD5A2 (0.79) SRD5A2SRD5A1ALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1017680-B1 TRICYCLIC COMPOUNDS, PREPARATION METHOD AND SAID METHOD INTERMEDIATES, APPLICATION AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AVENTIS PHARMA SA (FR) 2007-02-07 EP disclosed