Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.69 |
| ▸ | MAOA | P21397 | 2/20 | 0.69 |
| ▸ | PRKCI | P41743 | 1/20 | 0.69 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.56 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 5/20 | 0.45 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7637788 | 0.86 | PBRM1 (0.68) | MAOBMAOAPRKCIHSD17B1PBRM1 | |
| SCHEMBL389710 | 0.85 | MAOB (0.78) | MAOBMAOAPRKCIHSD17B1PBRM1 | |
| SCHEMBL228128 | 0.82 | MAOA (1.00) | MAOBMAOAPRKCIHSD17B1PBRM1 | |
| SCHEMBL7974509 | 0.79 | CASP1 (0.44) | MAOBMAOAPRKCIHSD17B1PBRM1 | |
| SCHEMBL5204433 | 0.79 | SRD5A2 (0.55) | MAOBMAOAPRKCIHSD17B1CASP1 | |
| SCHEMBL3825921 | 0.78 | MAOA (0.92) | MAOBMAOAPRKCIHSD17B1PBRM1 | |
| SCHEMBL23142696 | 0.76 | MAOB (0.58) | MAOBMAOAPRKCIHSD17B1PBRM1 | |
| SCHEMBL784291 | 0.74 | MAOB (0.59) | MAOBMAOAPRKCIHSD17B1PBRM1 | |
| SCHEMBL7716113 | 0.74 | PTPRC (0.46) | MAOBMAOAPRKCIHSD17B10HSP90AA1 | |
| SCHEMBL7976822 | 0.72 | ALDH1A1 (0.39) | MAOBMAOAPRKCIHSD17B1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017680-B1 | TRICYCLIC COMPOUNDS, PREPARATION METHOD AND SAID METHOD INTERMEDIATES, APPLICATION AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2007-02-07 | — | — | EP | disclosed |
| US-6459001-B1 | Tricyclic compounds, their preparation process and the intermediates of this process, their use as medicaments and the pharmaceutical compositions containing them | AVENTIS PHARMA S.A. (FR) | 2002-10-01 | — | — | US | disclosed |
| US-6339082-B1 | FOR THERAPY OF DISEASES CAUSED BY LOSS OF BONE MATRIX | AVENTIS PHARMA S.A. (FR) | 2002-01-15 | — | — | US | disclosed |
| EP-0888292-B1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY ALPHAvBETA3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6221907-B1 | Tricyclic compounds having activity specific for integrins, particularly alphanubeta3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same | HOECHST MARION ROUSSEL (FR) | 2001-04-24 | — | — | US | disclosed |
| EP-0888292-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY $g(a)v$g(b)3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | HOECHST MARION ROUSSEL (FR) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034865-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY αvβ3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | HOECHST MARION ROUSSEL (FR) | 1997-09-25 | — | — | WO | disclosed |