Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT2 | O60551 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | CDC25A | P30304 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | CDC25C | P30307 | 1/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236197 | 0.83 | MAPK14 (0.41) | NMT2NMT1HTR2AHTR2CSLC6A4 | |
| SCHEMBL5240413 | 0.83 | NMT2 (0.42) | NMT2NMT1HTR2AHTR2CSLC6A4 | |
| SCHEMBL5207062 | 0.81 | MAPK14 (0.38) | NMT2NMT1MAPK14KAT2BCDC25A | |
| SCHEMBL5203025 | 0.79 | HTR2A (0.38) | HTR2AHTR2CSLC6A4MAPK14MCHR1 | |
| SCHEMBL5204609 | 0.77 | MCHR1 (0.38) | HTR2AHTR2CSLC6A4MAPK14MCHR1 | |
| SCHEMBL5207713 | 0.69 | MAPK14 (0.44) | MAPK14 | |
| SCHEMBL5280738 | 0.67 | MCHR1 (0.42) | MAPK14MCHR1 | |
| SCHEMBL5205590 | 0.67 | MAOB (0.39) | MAPK14 | |
| SCHEMBL5209399 | 0.65 | MAPK14 (0.43) | MAPK14HTR6 | |
| SCHEMBL3522561 | 0.65 | MAPK14 (0.59) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802590-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | Pharmacia & Upjohn Company LLC (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040666-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-04-20 | — | — | WO | disclosed |