Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201788 | 0.91 | OPRM1 (0.47) | OPRM1OPRL1OPRK1SIGMAR1MCHR1 | |
| SCHEMBL5204015 | 0.89 | OPRM1 (0.47) | OPRM1OPRL1OPRK1SIGMAR1HTR2A | |
| SCHEMBL5202784 | 0.85 | OPRM1 (0.49) | OPRM1OPRL1OPRK1SIGMAR1MCHR1 | |
| SCHEMBL5204148 | 0.85 | HTR2A (0.47) | OPRM1OPRL1OPRK1HTR2AHTR7 | |
| SCHEMBL5204575 | 0.81 | OPRM1 (0.47) | OPRM1OPRL1OPRK1SIGMAR1MCHR1 | |
| SCHEMBL5202790 | 0.77 | OPRM1 (0.50) | OPRM1OPRL1OPRK1 | |
| SCHEMBL5206848 | 0.76 | SIGMAR1 (0.44) | OPRM1SIGMAR1CCR5DRD2KCNH2 | |
| SCHEMBL5204586 | 0.74 | OPRM1 (0.47) | OPRM1OPRL1OPRK1 | |
| SCHEMBL5204028 | 0.74 | SIGMAR1 (0.42) | OPRM1SIGMAR1CCR5DRD2KCNH2 | |
| SCHEMBL30076474 | 0.69 | OPRM1 (0.44) | OPRM1OPRL1OPRK1HTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1179532-B1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | EISAI R&D MAN CO LTD (JP) | 2007-06-13 | — | — | EP | disclosed |
| US-6573384-B1 | 1,4-substituted cyclic amine compound which is useful as a pharmaceutical, and an intermediate for the process | EISAI CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-1179532-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | Eisai Co., Ltd. (JP) | 2002-02-13 | — | — | EP | disclosed |