Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.74 |
| ▸ | CA1 | P00915 | 1/20 | 0.74 |
| ▸ | CA2 | P00918 | 1/20 | 0.74 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.74 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.74 |
| ▸ | ITGAL | P20701 | 1/20 | 0.74 |
| ▸ | CA4 | P22748 | 1/20 | 0.74 |
| ▸ | CA6 | P23280 | 1/20 | 0.74 |
| ▸ | AHR | P35869 | 1/20 | 0.74 |
| ▸ | ADK | P55263 | 1/20 | 0.74 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indole SCHEMBL27631042 | 1.00 | TRPA1 (0.74) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL29160563 | 0.94 | TRPA1 (0.71) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL384964 | 0.94 | TRPA1 (0.71) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL712897 | 0.92 | TRPA1 (0.68) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL28479409 | 0.89 | TRPA1 (0.77) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL28457095 | 0.89 | AHR (0.85) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL6791278 | 0.89 | AHR (0.85) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL6925060 | 0.88 | TRPA1 (0.63) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL9185264 | 0.88 | TRPA1 (0.63) | TRPA1CA1CA2ITGB2ICAM1 | |
| Indole SCHEMBL30721 | 0.88 | TRPA1 (0.63) | TRPA1CA1CA2ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108003112-A | Preparation among a kind of heterocyclic urea indoles amine -2,3- dioxygenase inhibitors | 上海晋鲁医药科技有限公司 | 2018-05-08 | — | — | CN | claimed |
| US-20240002405-A1 | ANTIMICROBIAL COMPOUNDS, SYNTHESIS METHODS, AND USES THEREOF | ANKH LIFE SCIENCES LIMITED (IE) | 2024-01-04 | — | — | US | disclosed |
| WO-2023235782-A2 | ANTIMICROBIAL COMPOUNDS, SYNTHESIS METHODS, AND USES THEREOF | ANKH LIFE SCIENCES LIMITED (IE) | 2023-12-07 | — | — | WO | disclosed |
| CN-113248491-B | Substituted indole urea derivatives, synthesis method and application thereof | 中国科学院上海药物研究所 | 2022-02-25 | — | — | CN | disclosed |
| CN-113248491-B | Substituted indole urea derivatives, synthesis method and application thereof | 中国科学院上海药物研究所 | 2022-02-25 | — | — | CN | disclosed |
| CN-113248491-A | Substituted indole urea derivatives, synthesis method and application thereof | 中国科学院上海药物研究所 | 2021-08-13 | — | — | CN | disclosed |
| CN-113248491-A | Substituted indole urea derivatives, synthesis method and application thereof | 中国科学院上海药物研究所 | 2021-08-13 | — | — | CN | disclosed |
| CN-110128493-A | The salt and its preparation method and application of pyranose substituted heterocyclic compound | 亚宝药业集团股份有限公司 | 2019-08-16 | — | — | CN | disclosed |
| CN-107118209-B | Pyrido [3,4-b ] indolylurea compounds and application thereof as IDO (intermediate compound) inhibitor | 西华大学 | 2019-06-25 | — | — | CN | disclosed |
| CN-106866571-B | Heterocyclic urea compound and its pharmaceutical composition and application | 中国药科大学 | 2018-06-29 | — | — | CN | disclosed |
| WO-1998028357-A1 | BIODEGRADABLE TARGETABLE MICROPARTICLE DELIVERY SYSTEM | CONNAUGHT LABORATORIES LIMITED (CA) | 1998-07-02 | — | — | WO | disclosed |
| EP-0544819-B1 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 1995-12-06 | — | — | EP | disclosed |
| US-5459150-A | Treatment of allergies and inflammatory diseases | ABBOTT LABORATORIES (US) | 1995-10-17 | — | — | US | disclosed |
| EP-0544819-A4 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS | — | 1993-10-20 | — | — | EP | disclosed |
| CN-1076197-A | The preparation method of indole urea derivative | BEECHAM GROUP PLC (GB) | 1993-09-15 | — | — | CN | disclosed |
| CN-1076197-A | The preparation method of indole urea derivative | BEECHAM GROUP PLC (GB) | 1993-09-15 | — | — | CN | disclosed |
| CN-1076197-A | The preparation method of indole urea derivative | BEECHAM GROUP PLC (GB) | 1993-09-15 | — | — | CN | disclosed |
| EP-0544819-A1 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS. | ABBOTT LAB (US) | 1993-06-09 | — | — | EP | disclosed |
| US-5095031-A | Enzyme inhibitors, antiallergens, antiinflammatory | ABBOTT LABORATORIES (US) | 1992-03-10 | — | — | US | disclosed |
| WO-1992003132-A1 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1992-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240002405-A1 | ANTIMICROBIAL COMPOUNDS, SYNTHESIS METHODS, AND USES THEREOF | NOD2, MPO, LSS | TRPA1 1390/4885CA1 3874/4885CA2 3183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.