Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201956 | 0.92 | KCNH2 (0.43) | HTR2AOPRM1 | |
| SCHEMBL5204747 | 0.91 | CACNA1G (0.49) | HTR2AHTR2CHTR7HTR6OPRM1 | |
| SCHEMBL5201930 | 0.88 | HTR2A (0.47) | HTR2AHTR2CHTR7HTR6OPRM1 | |
| SCHEMBL5206812 | 0.87 | SIGMAR1 (0.40) | HTR2AHTR2COPRM1HRH1 | |
| SCHEMBL5206848 | 0.86 | SIGMAR1 (0.44) | OPRM1 | |
| SCHEMBL5206815 | 0.84 | SLC22A12 (0.44) | OPRM1 | |
| SCHEMBL5204477 | 0.82 | KCNH2 (0.42) | HTR2AOPRM1 | |
| SCHEMBL5872415 | 0.80 | HTR2A (0.47) | HTR2AHTR2CHTR7HTR6OPRM1 | |
| SCHEMBL5207344 | 0.79 | CACNA1G (0.49) | HTR2AHTR2CHTR7HTR6OPRM1 | |
| SCHEMBL5204028 | 0.77 | SIGMAR1 (0.42) | OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1179532-B1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | EISAI R&D MAN CO LTD (JP) | 2007-06-13 | — | — | EP | disclosed |
| US-6573384-B1 | 1,4-substituted cyclic amine compound which is useful as a pharmaceutical, and an intermediate for the process | EISAI CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-1179532-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | Eisai Co., Ltd. (JP) | 2002-02-13 | — | — | EP | disclosed |