Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.51 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.49 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.49 |
| ▸ | BCL6 | P41182 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5203439 | 0.99 | SCN9A (0.50) | SCN9AKCNH2SCN5ATTBK1TTBK2 | |
| SCHEMBL6480285 | 0.88 | AURKA (0.53) | TTBK1TTBK2AURKA | |
| SCHEMBL6472908 | 0.88 | TTBK1 (0.43) | SCN9AKCNH2SCN5ATTBK1TTBK2 | |
| SCHEMBL6481407 | 0.88 | AURKA (0.47) | SCN9AKCNH2SCN5ATTBK1TTBK2 | |
| SCHEMBL6474471 | 0.87 | BCL6 (0.49) | SCN9ASCN5ATTBK1TTBK2BCL6 | |
| SCHEMBL5204374 | 0.86 | SCN9A (0.44) | SCN9AKCNH2SCN5ATTBK1TTBK2 | |
| SCHEMBL5204470 | 0.86 | MEN1 (0.42) | SCN9AKCNH2SCN5ATTBK1TTBK2 | |
| SCHEMBL5203892 | 0.85 | SCN9A (0.46) | SCN9AKCNH2SCN5ATTBK1TTBK2 | |
| SCHEMBL6482628 | 0.84 | BCL6 (0.44) | SCN9AKCNH2SCN5ABCL6AURKA | |
| SCHEMBL6480339 | 0.84 | MAPT (0.44) | AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | claimed |