Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | CTSK | P43235 | 5/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206542 | 0.89 | CTSK (0.58) | CTSLCTSSCTSKSIRT2SIRT1 | |
| SCHEMBL3877327 | 0.83 | CACNA1B (0.57) | CTSLCTSSCTSKLMNAMAPT | |
| SCHEMBL1119084 | 0.82 | CTSL (0.56) | CTSLCTSSCTSKSIRT2SIRT1 | |
| SCHEMBL16465117 | 0.82 | CTSK (0.60) | CTSLCTSSCTSKSIRT2SIRT1 | |
| SCHEMBL751179 | 0.82 | CTSL (0.55) | CTSLCTSSCTSKSIRT2SIRT1 | |
| SCHEMBL3941405 | 0.82 | CTSL (0.57) | CTSLCTSSCTSKSIRT2SIRT1 | |
| SCHEMBL15569270 | 0.81 | CTSS (0.57) | CTSLCTSSCTSKSIRT2SIRT1 | |
| SCHEMBL15569565 | 0.80 | CTSS (0.55) | CTSLCTSSCTSKSIRT2SIRT1 | |
| SCHEMBL7761583 | 0.80 | CTSS (0.55) | CTSLCTSSCTSKSIRT2SIRT1 | |
| SCHEMBL5550159 | 0.80 | CTSS (0.55) | CTSLCTSSCTSKSIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551801-A4 | NOVEL GAMMA-LACTAMS AS BETA-SECRETASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-06-20 | — | — | EP | disclosed |
| EP-1551801-A1 | NOVEL GAMMA-LACTAMS AS BETA-SECRETASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004013098-A1 | NOVEL GAMMA-LACTAMS AS BETA-SECRETASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-02-12 | — | — | WO | disclosed |