Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.55 |
| ▸ | CTSS | P25774 | 2/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 6/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.47 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19123985 | 0.95 | CTSL (0.57) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL47273 | 0.95 | CTSL (0.57) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL18030283 | 0.91 | BCHE (0.57) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL6471138 | 0.91 | CTSL (0.53) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL6638775 | 0.90 | SIRT2 (0.55) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL5206542 | 0.89 | CTSK (0.58) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL1119084 | 0.89 | CTSL (0.56) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL3941405 | 0.88 | CTSL (0.57) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL6254290 | 0.88 | CASP1 (0.57) | CTSLCTSSALDH1A1CYP3A4TSHR | |
| SCHEMBL4452037 | 0.88 | CASP1 (0.57) | CTSLCTSSALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430014-A1 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132601-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |