Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.53 |
| ▸ | CFD | P00746 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 4/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MDM4 | O15151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970042 | 1.00 | PIN1 (0.53) | PIN1CFDCASP3MDM2KMT2A | |
| SCHEMBL5202706 | 1.00 | PIN1 (0.53) | PIN1CFDCASP3MDM2KMT2A | |
| SCHEMBL5205826 | 0.90 | PIN1 (0.54) | PIN1CFDCASP3MDM2KMT2A | |
| SCHEMBL5205538 | 0.89 | PIN1 (0.53) | PIN1CFDCASP3MDM2KMT2A | |
| SCHEMBL5207070 | 0.89 | PIN1 (0.53) | PIN1CFDCASP3MDM2KMT2A | |
| SCHEMBL6966679 | 0.89 | PIN1 (0.53) | PIN1CFDCASP3MDM2KMT2A | |
| SCHEMBL5205519 | 0.85 | DPP4 (0.49) | PIN1 | |
| SCHEMBL5204641 | 0.85 | DPP4 (0.49) | PIN1 | |
| SCHEMBL6970048 | 0.82 | PIN1 (0.42) | PIN1CFDKMT2A | |
| SCHEMBL5206185 | 0.82 | PIN1 (0.42) | PIN1CFDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070112059-A1 | CYANOPYRROLIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. | 2007-05-17 | — | — | US | disclosed |
| US-20070112205-A1 | CYANOPYRROLIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. | 2007-05-17 | — | — | US | disclosed |
| EP-1746086-A1 | Cyanopyrrolidine derivatives | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2007-01-24 | — | — | EP | disclosed |
| US-20040072892-A1 | Cyanopyrrolidine derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2004-04-15 | — | — | US | disclosed |
| EP-1333025-A1 | CYANOPYRROLIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2003-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072892-A1 | Cyanopyrrolidine derivatives | CCR9, OPRD1, CBR1 | PIN1 4600/4885CFD 2124/4885CASP3 2798/4885 |
| US-20070112059-A1 | CYANOPYRROLIDINE DERIVATIVES | DPP4, DPP9, DPP3 | PIN1 804/4885CFD 685/4885CASP3 394/4885 |
| US-20070112205-A1 | CYANOPYRROLIDINE DERIVATIVES | CBR3, CBR1, TERT | PIN1 2350/4885CFD 983/4885CASP3 2508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.