Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206103 | 0.87 | OPRM1 (0.49) | OPRM1 | |
| SCHEMBL5373262 | 0.85 | ALDH1A1 (0.56) | MEN1KMT2ACCR3 | |
| SCHEMBL5202187 | 0.85 | SLC2A1 (0.53) | CCR3 | |
| SCHEMBL5205363 | 0.84 | F2 (0.44) | MEN1KMT2APOLB | |
| SCHEMBL27816805 | 0.83 | MEN1 (0.47) | OPRM1MEN1KMT2APOLB | |
| SCHEMBL14559864 | 0.82 | MEN1 (0.56) | OPRM1MEN1KMT2APOLBCCR3 | |
| SCHEMBL9768376 | 0.81 | RAB9A (0.54) | MEN1KMT2APOLBCCR3 | |
| SCHEMBL3813779 | 0.79 | HRH3 (0.49) | MEN1KMT2A | |
| SCHEMBL14559866 | 0.78 | MEN1 (0.53) | OPRM1MEN1KMT2APOLBCCR3 | |
| SCHEMBL8485315 | 0.78 | ALDH1A1 (0.51) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565453-A4 | 2- (4-BENZYL)-1-PIPERIDINYL)METHYL|BENZIMIDAZOLE-5-OL DERIVATIVES AS NR2B RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2007-10-10 | — | — | EP | disclosed |
| EP-1565453-A1 | 2- (4-BENZYL)-1-PIPERIDINYL)METHYL]BENZIMIDAZOLE-5-OL DERIVATIVES AS NR2B RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004048364-A1 | 2-[(4-BENZYL)-1-PIPERIDINYL)METHYL]BENZIMIDAZOLE-5-OL DERIVATIVES AS NR2B RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2004-06-10 | — | — | WO | disclosed |