Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205820 | 0.82 | HRH2 (0.42) | LMNAL3MBTL1HRH2KMT2A | |
| SCHEMBL4851493 | 0.82 | MEN1 (0.45) | HRH2MEN1KMT2A | |
| SCHEMBL4854486 | 0.82 | ALDH1A1 (0.46) | HSD11B1L3MBTL1HRH2MEN1KMT2A | |
| SCHEMBL4860552 | 0.82 | HRH2 (0.46) | LMNAL3MBTL1HRH2KMT2A | |
| SCHEMBL4859778 | 0.81 | SLC2A1 (0.49) | LMNAMEN1KMT2A | |
| SCHEMBL4854494 | 0.79 | HRH2 (0.46) | LMNAPDE3AHSD11B1HRH2PDE2A | |
| SCHEMBL5202530 | 0.79 | ALDH1A1 (0.42) | LMNAKMT2ACREBBP | |
| SCHEMBL5204405 | 0.74 | EPHX2 (0.49) | LMNAPDE4BEPHX2MEN1KMT2A | |
| SCHEMBL4859493 | 0.73 | ALDH1A1 (0.50) | LMNAMEN1KMT2ACREBBP | |
| SCHEMBL5203062 | 0.73 | HCRTR1 (0.49) | LMNAHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |