Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203151 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAPTKMT2ACREBBP | |
| SCHEMBL4854486 | 0.79 | ALDH1A1 (0.46) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL4860552 | 0.79 | HRH2 (0.46) | ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL4851493 | 0.79 | MEN1 (0.45) | KMT2ANPC1 | |
| SCHEMBL5205820 | 0.79 | HRH2 (0.42) | MAPTKMT2ALMNANPC1 | |
| SCHEMBL5206637 | 0.79 | LMNA (0.44) | KMT2ACREBBPLMNA | |
| SCHEMBL5204457 | 0.77 | HTR2A (0.44) | ALDH1A1KMT2ALMNANPC1 | |
| SCHEMBL4859493 | 0.76 | ALDH1A1 (0.50) | ALDH1A1MAPTKMT2ACREBBPLMNA | |
| SCHEMBL4854494 | 0.76 | HRH2 (0.46) | ALDH1A1KDM4EMAPTKMT2ALMNA | |
| SCHEMBL5204952 | 0.75 | HRH2 (0.55) | ALDH1A1KDM4ECNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |
| EP-1654253-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005019208-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2005-03-03 | — | — | WO | disclosed |