Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 4/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851493 | 0.91 | MEN1 (0.45) | HRH2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL4854486 | 0.83 | ALDH1A1 (0.46) | HRH2L3MBTL1KMT2A | |
| SCHEMBL4860552 | 0.83 | HRH2 (0.46) | HRH2L3MBTL1RAB9ALMNAMAPT | |
| SCHEMBL4854494 | 0.83 | HRH2 (0.46) | HRH2LMNAUBE2MDCUN1D1MAPT | |
| SCHEMBL5206637 | 0.82 | LMNA (0.44) | HRH2L3MBTL1LMNAKMT2A | |
| SCHEMBL4862005 | 0.81 | SLC5A1 (0.51) | HRH2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL5202530 | 0.79 | ALDH1A1 (0.42) | NPC1LMNAMAPTKMT2A | |
| SCHEMBL5203757 | 0.77 | NPC1 (0.57) | HRH2L3MBTL1NPC1RAB9AATM | |
| SCHEMBL5201910 | 0.77 | NPC1 (0.42) | HRH2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL5204533 | 0.76 | ALDH1A1 (0.46) | HRH2HDAC3HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |