Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851454 | 0.81 | HTR6 (0.43) | HCRTR1HCRTR2LMNAPOLBTHRB | |
| SCHEMBL5204228 | 0.81 | EPHX2 (0.44) | LMNAPOLBTHRBALDH1A1MAPT | |
| SCHEMBL5206126 | 0.79 | KMT2A (0.42) | LMNAPOLBALDH1A1HTR6 | |
| SCHEMBL5202889 | 0.74 | HPN (0.52) | LMNAPOLBTHRBALDH1A1HTR6 | |
| SCHEMBL5205820 | 0.74 | HRH2 (0.42) | LMNAMAPTHPGDHRH2 | |
| SCHEMBL4860552 | 0.74 | HRH2 (0.46) | LMNAALDH1A1MAPTHRH2 | |
| SCHEMBL4854486 | 0.74 | ALDH1A1 (0.46) | NPSR1ALDH1A1HRH2 | |
| SCHEMBL5202530 | 0.74 | ALDH1A1 (0.42) | LMNAALDH1A1MAPT | |
| SCHEMBL4851493 | 0.74 | MEN1 (0.45) | HSD17B10HTR6HRH2 | |
| SCHEMBL5206637 | 0.73 | LMNA (0.44) | LMNAHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |