Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 14/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210888 | 0.88 | CRHR1 (0.48) | CRHR1HSP90AA1HSP90AB1MAPTNPC1 | |
| SCHEMBL5207986 | 0.82 | CRHR1 (0.44) | CRHR1HSP90AA1MAPTL3MBTL1 | |
| SCHEMBL5246749 | 0.77 | CRHR1 (1.00) | CRHR1HSP90AA1HSP90AB1MAPTL3MBTL1 | |
| SCHEMBL5209663 | 0.75 | MAPT (0.44) | CRHR1HSP90AA1MAPTL3MBTL1 | |
| SCHEMBL19953463 | 0.75 | MAPT (0.53) | CRHR1HSP90AA1MAPTL3MBTL1 | |
| SCHEMBL6345878 | 0.75 | DHODH (0.41) | — | |
| SCHEMBL3364325 | 0.70 | NPC1 (0.42) | CRHR1NPC1 | |
| SCHEMBL6834931 | 0.70 | CRHR1 (0.69) | CRHR1 | |
| SCHEMBL461099 | 0.70 | MAPT (0.69) | CRHR1MAPTL3MBTL1 | |
| SCHEMBL5209552 | 0.70 | HSD11B1 (0.46) | CRHR1HSP90AA1HSP90AB1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341793-B1 | CRF RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES INC (US) | 2007-01-17 | — | — | EP | disclosed |
| US-6974808-B2 | CRF receptor antagonists and methods relating thereto | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-12-13 | — | — | US | disclosed |
| US-20040266799-A1 | CRF receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. | 2004-12-30 | — | — | US | disclosed |
| US-6747034-B2 | CORTICOTROPIN-RELEASING FACTOR (CRF); SUCH AS 4-CHLORO-2-METHYL-5-NITRO-8-(2,4-DICHLORO)PHENYL-1,7-NAPHTHYRIDINE FOR TREATING STROKE, ANXIETY, DEPRESSION, AND/OR IRRITABLE BOWEL SYNDROME | NEUROCRINE BIOSCIENCES, INC. | 2004-06-08 | — | — | US | disclosed |
| US-20020151557-A1 | CRF receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC | 2002-10-17 | — | — | US | disclosed |
| US-20020049207-A1 | CRF receptor antagonists and methods relating thereto | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-04-25 | — | — | US | disclosed |
| US-6352990-B1 | A METHOD OF TREATING ANXIETY AND DEPRESSION IN A WARM-BLOODED ANIMAL AND TREATMENT OF STROKES | BRISTOL-MYERS SQUIBB COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-0970082-A2 | BIAZACYCLIC CRF ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998035967-A2 | BIAZACYCLIC CRF ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 1998-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266799-A1 | CRF receptor antagonists and methods relating thereto | CRHR1, CRH, CRHR2 | CRHR1 1/4885HSP90AA1 491/4885HSP90AB1 661/4885 |
| US-20020049207-A1 | CRF receptor antagonists and methods relating thereto | CRHR1, CRH, CRHR2 | CRHR1 1/4885HSP90AA1 491/4885HSP90AB1 661/4885 |
| US-20020151557-A1 | CRF receptor antagonists and methods relating thereto | CRHR1, CRH, CRHR2 | CRHR1 1/4885HSP90AA1 491/4885HSP90AB1 661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.