Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.35 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203455 | 0.88 | TTR (0.40) | BCL6SLC6A2SLC6A4POLBSLC6A3 | |
| SCHEMBL5207953 | 0.86 | SLC6A2 (0.44) | SLC6A2SLC6A4KCNH2POLBSLC6A3 | |
| SCHEMBL5206090 | 0.84 | BCL6 (0.42) | BCL6SLC6A2SLC6A4SLC6A3STK17A | |
| SCHEMBL5205013 | 0.82 | KCNH2 (0.40) | KCNH2POLBSTK17ACYP2D6CYP2C19 | |
| SCHEMBL5202529 | 0.76 | MET (0.41) | SLC6A2SLC6A4KCNH2METKDR | |
| SCHEMBL5203505 | 0.76 | MAPK14 (0.43) | METSGK1 | |
| SCHEMBL5203513 | 0.76 | MAPK14 (0.43) | METSGK1 | |
| SCHEMBL1376217 | 0.75 | NUDT1 (0.43) | KCNH2STK17ASCN9A | |
| SCHEMBL5202871 | 0.74 | STK17A (0.42) | KCNH2STK17ASCN9A | |
| SCHEMBL1376097 | 0.74 | STK17A (0.41) | KCNH2STK17ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |