Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | SELE | P16581 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203455 | 0.88 | TTR (0.40) | SLC6A2SLC6A4SLC6A3CYP2C19L3MBTL1 | |
| SCHEMBL5207181 | 0.86 | BCL6 (0.40) | SLC6A2SLC6A4SLC6A3CYP2C19KCNH2 | |
| SCHEMBL5205013 | 0.82 | KCNH2 (0.40) | CYP1A2CYP2C19KCNH2POLBALDH1A1 | |
| SCHEMBL5206090 | 0.80 | BCL6 (0.42) | SLC6A2SLC6A4SLC6A3CYP2C19ALDH1A1 | |
| SCHEMBL6474741 | 0.79 | SCN5A (0.42) | SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL7510625 | 0.77 | RXFP1 (0.41) | CYP2C19L3MBTL1ALDH1A1NUDT1 | |
| SCHEMBL5205294 | 0.77 | MMP13 (0.40) | KCNH2ALDH1A1NUDT1NPSR1 | |
| SCHEMBL6474559 | 0.77 | GAA (0.43) | SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL5206507 | 0.76 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL1376410 | 0.76 | MERTK (0.39) | SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |