Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 2/20 | 0.42 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17426 | 0.87 | SLC1A1 (0.50) | SLC1A1HTTSMN1; SMN2GHSRCTSS | |
| SCHEMBL9990986 | 0.87 | SLC1A1 (0.50) | SLC1A1HTTSMN1; SMN2GHSRCTSS | |
| SCHEMBL7398925 | 0.84 | SLC15A1 (0.51) | LTA4H | |
| SCHEMBL3586820 | 0.84 | SLC1A1 (0.52) | SLC1A1HTTSMN1; SMN2CA7CA9 | |
| SCHEMBL3580688 | 0.82 | HTT (0.50) | SLC1A1HTTSMN1; SMN2CTSSTACR1 | |
| SCHEMBL3580682 | 0.82 | HTT (0.50) | SLC1A1HTTSMN1; SMN2CTSSTACR1 | |
| Trifluoroacetic Acid SCHEMBL25141 | 0.81 | SLC1A1 (0.45) | SLC1A1CTSS | |
| SCHEMBL1576805 | 0.81 | SLC1A1 (0.55) | SLC1A1HTTSMN1; SMN2CA12CA7 | |
| SCHEMBL13165228 | 0.80 | SLC1A1 (0.54) | SLC1A1HTTSMN1; SMN2ALDH1A1LTA4H | |
| SCHEMBL14580892 | 0.80 | SLC1A1 (0.54) | SLC1A1HTTSMN1; SMN2ALDH1A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175213-A4 | HETEROCYCLIC AROMATIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES | BRISTOL MYERS SQUIBB CO (US) | 2007-04-11 | — | — | EP | disclosed |
| US-7053110-B2 | Heterocyclic aromatic compounds useful as growth hormone secreagogues | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-30 | — | — | US | disclosed |
| US-6969727-B2 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-11-29 | — | — | US | disclosed |
| US-6908938-B2 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-06-21 | — | — | US | disclosed |
| US-20040072881-A1 | Heterocyclic aromatic compounds useful as growth hormone secreagogues | ROBL JEFFREY A (US) | 2004-04-15 | — | — | US | disclosed |
| US-20040029935-A1 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | ROBL JEFFREY A (US) | 2004-02-12 | — | — | US | disclosed |
| US-20040002525-A1 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | A ROBL JEFFREY (US) | 2004-01-01 | — | — | US | disclosed |
| US-6660760-B1 | Treating obesity, osteoporosis | BRISTOL-MYERS SQUIBB CO. | 2003-12-09 | — | — | US | disclosed |
| US-6525203-B1 | Treating obesity, osteoporosis by improving bone density and stimulating increase in muscle mass and strength | BRISTOL-MYERS SQUIBB COMPANY | 2003-02-25 | — | — | US | disclosed |
| US-6518292-B1 | Stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength | BRISTOL-MYERS SQUIBB CO. | 2003-02-11 | — | — | US | disclosed |
| EP-1175213-A2 | HETEROCYCLIC AROMATIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000054729-A2 | HETEROCYCLIC AROMATIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072881-A1 | Heterocyclic aromatic compounds useful as growth hormone secreagogues | GHSR, GHRHR, SHBG | SLC1A1 2463/4885HTT 1329/4885SMN1; SMN2 1325/4885 |
| US-20040002525-A1 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | GHSR, GHRHR, NPY4R | SLC1A1 3248/4885HTT 698/4885SMN1; SMN2 1071/4885 |
| US-20040029935-A1 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | GHSR, GHRHR, NPY4R | SLC1A1 3248/4885HTT 698/4885SMN1; SMN2 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.