SCHEMBL5211178

SCHEMBL5211178

O=C1CCCc2ccc(-c3ccccc3)cc21

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.58
MAOB P27338 6/20 0.58
CYP2A6 P11509 1/20 0.58
HSD17B1 P14061 2/20 0.54
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
NPC1 O15118 2/20 0.53
MAPT P10636 2/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
KDM4E B2RXH2 1/20 0.53
USP2 O75604 1/20 0.53
ALDH1A1 P00352 1/20 0.53
HPGD P15428 1/20 0.53
TYRO3 Q06418 1/20 0.51
NTRK2 Q16620 1/20 0.51
CLK4 Q9HAZ1 1/20 0.51
DYRK1B Q9Y463 1/20 0.51
GRM5 P41594 1/20 0.47
TDP2 O95551 1/20 0.46
LMNA P02545 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29395799 1.00 MAOA (0.58) MAOAMAOBCYP2A6HSD17B1MEN1
SCHEMBL7180348 0.89 MEN1 (0.56) MAOAMAOBCYP2A6HSD17B1MEN1
SCHEMBL19686137 0.88 MAOA (0.49) MAOAMAOBCYP2A6HSD17B1MEN1
SCHEMBL7584101 0.86 HSD17B1 (0.73) MAOAMAOBCYP2A6HSD17B1MEN1
SCHEMBL5211345 0.84 HSD17B1 (0.53) MAOAMAOBCYP2A6HSD17B1MEN1
SCHEMBL5204318 0.84 MAOA (0.57) MAOAMAOBCYP2A6HSD17B1MEN1
SCHEMBL16821225 0.83 PARP10 (0.50) MAOAMAOBCYP2A6HSD17B1MEN1
SCHEMBL27844082 0.82 HSD17B1 (0.51) MAOAMAOBCYP2A6HSD17B1MEN1
SCHEMBL27843881 0.82 HSD17B1 (0.51) MAOAMAOBCYP2A6HSD17B1MEN1
SCHEMBL21222886 0.82 HSD17B1 (0.68) MAOAMAOBCYP2A6HSD17B1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4573086-A1 METHANOGEN INHIBITORS Agrizeronz Limited Partnership (NZ) 2025-06-25 EP disclosed
CN-119998272-A Methanogen inhibitors 阿格里泽伦茨有限合伙公司 2025-05-13 CN disclosed
WO-2024039250-A1 METHANOGEN INHIBITORS PASTORAL GREENHOUSE GAS RESEARCH LIMITED (NZ) 2024-02-22 WO disclosed
US-20230286917-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2023-09-14 US disclosed
US-20230286917-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2023-09-14 US disclosed
US-20230286917-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2023-09-14 US disclosed
US-11639333-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC (US) 2023-05-02 US disclosed
US-11639333-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC (US) 2023-05-02 US disclosed
US-11639333-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC (US) 2023-05-02 US disclosed
EP-3561876-B1 DISPLAY NOVALED GMBH (DE) 2022-02-16 EP disclosed
WO-1996001267-A1 PHOSPHONIC ACID COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-01-18 WO disclosed
EP-0671172-A1 AMINO ACID DERIVATIVE Eisai Co., Ltd. (JP) 1995-09-13 EP disclosed
US-5401735-A Antibiotics for gramnegative or grampositive bacteria MERCK & CO., INC. (US) 1995-03-28 US disclosed
WO-1995003700-A1 BRIDGED BIPHENYL CARBAPENEM ANTIBACTERIAL COMPOUNDS MERCK & CO., INC. (US) 1995-02-09 WO disclosed
WO-1995003699-A1 BRIDGED BIPHENYL CARBAPENEM COMPOUNDS AND METHODS OF USE MERCK & CO., INC. (US) 1995-02-09 WO disclosed
US-5384317-A Bactericides MERCK & CO., INC. (US) 1995-01-24 US disclosed
WO-1994028718-A1 BRIDGED CARBAPENEM COMPOUNDS, COMPOSITIONS AND METHODS OF USE MERCK & CO., INC. (US) 1994-12-22 WO disclosed
WO-1994028719-A1 BRIDGED CARBAPENEM ANTIBACTERIAL COMPOUNDS MERCK & CO., INC. (US) 1994-12-22 WO disclosed
US-5374630-A Bridged carbapenem antibacterial compounds MERCK & CO., INC. (US) 1994-12-20 US disclosed
US-5372993-A Bridged carbapenem compounds, compositions containing such compounds and methods of use MERCK & CO., INC. (US) 1994-12-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230286917-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM5A, KDM1A MAOA 430/4885MAOB 473/4885CYP2A6 1919/4885
US-11639333-B2 Histone demethylase inhibitors KDM1B, KDM5A, KDM1A MAOA 430/4885MAOB 473/4885CYP2A6 1919/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.