SCHEMBL5211345

SCHEMBL5211345

O=C1CCCc2ccc(-c3ccc(F)cc3)cc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 4/20 0.53
MAOA P21397 6/20 0.47
MAOB P27338 6/20 0.47
CYP2A6 P11509 1/20 0.47
HRH3 Q9Y5N1 3/20 0.43
PRKCI P41743 1/20 0.42
MEN1 O00255 1/20 0.42
MAPK1 P28482 1/20 0.42
KMT2A Q03164 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
PBRM1 Q86U86 1/20 0.41
PARP1 P09874 1/20 0.40
PARP10 Q53GL7 1/20 0.40
CYP17A1 P05093 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP11B1 P15538 1/20 0.40
CYP11B2 P19099 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
BRD4 O60885 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7506302 0.86 HSD17B1 (0.71) HSD17B1MAOAMAOBCYP2A6HRH3
SCHEMBL29446042 0.85 MAOA (0.53) HSD17B1MAOAMAOBCYP2A6PRKCI
SCHEMBL769238 0.85 MAOA (0.53) HSD17B1MAOAMAOBCYP2A6PRKCI
SCHEMBL16821225 0.85 PARP10 (0.50) HSD17B1MAOAMAOBCYP2A6HRH3
SCHEMBL29395799 0.84 MAOA (0.58) HSD17B1MAOAMAOBCYP2A6PRKCI
SCHEMBL5211178 0.84 MAOA (0.58) HSD17B1MAOAMAOBCYP2A6PRKCI
SCHEMBL5204318 0.83 MAOA (0.57) HSD17B1MAOAMAOBCYP2A6PRKCI
SCHEMBL4017169 0.82 PARP1 (0.53) HSD17B1MAOAMAOBCYP2A6PRKCI
SCHEMBL7503492 0.80 MAOA (0.48) HSD17B1MAOAMAOBCYP2A6HRH3
SCHEMBL5209716 0.79 MAOA (0.57) HSD17B1MAOAMAOBCYP2A6PRKCI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1040103-B1 ANILIDE DERIVATIVE, PRODUCTION AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2007-03-14 EP disclosed
US-6413947-B1 Anilide derivative, production and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-07-02 US disclosed
US-6268354-B1 Pharmaceutical composition for antagonizing CCR5 comprising anilide derivative TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-07-31 US disclosed
CN-1282326-A Anilide derivative, process for producing the same, and use thereof TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2001-01-31 CN disclosed
US-6172061-B1 AIDS THERAPY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-09 US disclosed
US-6166006-A Anilide derivative, production and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-12-26 US disclosed
EP-1039899-A2 PHARMACEUTICAL COMPOSITION FOR ANTAGONIZING CCR5 COMPRISING ANILIDE DERIVATIVE Takeda Chemical Industries, Ltd. (JP) 2000-10-04 EP disclosed
EP-1040103-A1 ANILIDE DERIVATIVE, PRODUCTION AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-10-04 EP disclosed
WO-1999032100-A2 PHARMACEUTICAL COMPOSITION FOR ANTAGONIZING CCR5 COMPRISING ANILIDE DERIVATIVE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-07-01 WO disclosed
WO-1999032468-A1 ANILIDE DERIVATIVE, PRODUCTION AND USE THEREOF TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-07-01 WO disclosed