Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 8/20 | 0.53 |
| ▸ | MAOB | P27338 | 8/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.41 |
| ▸ | TYMS | P04818 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29446042 | 1.00 | MAOA (0.53) | MAOAMAOBCYP2A6PARP1PARP10 | |
| SCHEMBL4017169 | 0.96 | PARP1 (0.53) | MAOAMAOBCYP2A6PARP1PARP10 | |
| SCHEMBL1150109 | 0.88 | PBRM1 (0.59) | PARP1PARP10SRD5A1PBRM1ACHE | |
| SCHEMBL29443089 | 0.88 | PBRM1 (0.59) | PARP1PARP10SRD5A1PBRM1ACHE | |
| SCHEMBL5211345 | 0.85 | HSD17B1 (0.53) | MAOAMAOBCYP2A6PARP1PARP10 | |
| SCHEMBL315877 | 0.84 | MAOA (0.61) | MAOAMAOBCYP2A6PRKCIMEN1 | |
| SCHEMBL6835462 | 0.81 | PARP1 (0.44) | MAOAMAOBCYP2A6PARP1PARP10 | |
| SCHEMBL16821225 | 0.81 | PARP10 (0.50) | MAOAMAOBCYP2A6PARP10PRKCI | |
| SCHEMBL6835460 | 0.81 | PARP1 (0.44) | MAOAMAOBCYP2A6PARP1PARP10 | |
| SCHEMBL315222 | 0.80 | HTR2C (0.52) | MAOAMAOBCYP2A6PRKCIMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 263 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115108928-B | Nitrogen mustard-tetralone derivative, preparation method and application thereof | 广东海洋大学 | 2024-06-11 | — | — | CN | claimed |
| CN-115925530-A | 3,4-dihydronaphthalene-1 (2H) -ketone compound, preparation method and application | 滨州医学院 | 2023-04-07 | — | — | CN | claimed |
| US-12637414-B2 | Arylamides and methods of use thereof | GENZYME CORPORATION (US) | 2026-05-26 | — | — | US | disclosed |
| US-12630566-B2 | KRas G12D inhibitors | Mirati Therapeutics, Inc. (US) | 2026-05-19 | — | — | US | disclosed |
| US-20250388606-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2025-12-25 | — | — | US | disclosed |
| US-20250333371-A1 | COMPOUNDS | Psylo Pty Ltd (AU) | 2025-10-30 | — | — | US | disclosed |
| US-20250145639-A1 | MUTANT KRAS MODULATORS AND USES THEREOF | NEWAVE PHARMACEUTICAL INC (US) | 2025-05-08 | — | — | US | disclosed |
| WO-2025053850-A1 | COVALENT KRAS-BINDING COMPOUNDS FOR MEDICAL TREATMENT | HYKU BIOSCIENCES INC. (US) | 2025-03-13 | — | — | WO | disclosed |
| EP-4436571-A1 | SMALL MOLECULE INHIBITORS OF KRAS MUTATED PROTEINS | Merck Sharp & Dohme LLC (US) | 2024-10-02 | — | — | EP | disclosed |
| US-20240309020-A1 | KRAS G12D INHIBITORS | ARRAY BIOPHARMA INC. | 2024-09-19 | — | — | US | disclosed |
| CN-118556063-A | Heterocyclic compound, pharmaceutical composition and application thereof | 上海湃隆生物科技有限公司 | 2024-08-27 | — | — | CN | disclosed |
| US-4051233-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (US) | 1977-09-27 | — | — | US | disclosed |
| US-4051248-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS, NEUROLEPTIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1977-09-27 | — | — | US | disclosed |
| US-4048330-A | Compositions containing 2-(6'-substituted-2'-naphthyl)acetic acid esters used for treating inflammation, pain or pyrexia | SYNTEX CORPORATION (US) | 1977-09-13 | — | — | US | disclosed |
| US-4009197-A | 2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof | SYNTEX CORPORATION (PM) | 1977-02-22 | — | — | US | disclosed |
| US-4001301-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS, ANTI-PRURITIC | SYNTEX CORPORATION (PM) | 1977-01-04 | — | — | US | disclosed |
| US-3998966-A | Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic 6-substituted 2-naphthyl acetic acid derivative-containing compositions and methods of use thereof | SYNTEX CORPORATION (PM) | 1976-12-21 | — | — | US | disclosed |
| US-3980699-A | ANTIINFLAMMATORY, ANALGESICS, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (PM) | 1976-09-14 | — | — | US | disclosed |
| US-3978124-A | ANALGESIC, ANTIPYRETIC | SYNTEX CORPORATION (PM) | 1976-08-31 | — | — | US | disclosed |
| US-3978116-A | ANALGESIC, ANTIPYRETIC | SYNTEX CORPORATION (PM) | 1976-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12637414-B2 | Arylamides and methods of use thereof | CFTR, CLIC1, ABCC1 | MAOA 2504/4885MAOB 2294/4885CYP2A6 98/4885 |
| US-12630566-B2 | KRas G12D inhibitors | KRAS, NRAS, HRAS | MAOA 4861/4885MAOB 4814/4885CYP2A6 3178/4885 |
| US-20250145639-A1 | MUTANT KRAS MODULATORS AND USES THEREOF | KRAS, NRAS, FOXM1 | MAOA 4791/4885MAOB 4500/4885CYP2A6 2081/4885 |
| US-20250333371-A1 | COMPOUNDS | SDHA, PYGB, SLC18A2 | MAOA 29/4885MAOB 6/4885CYP2A6 185/4885 |
| US-20250388606-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | KRAS, NRAS, HRAS | MAOA 4851/4885MAOB 4754/4885CYP2A6 3071/4885 |
| US-20240309020-A1 | KRAS G12D INHIBITORS | KRAS, NRAS, HRAS | MAOA 4870/4885MAOB 4846/4885CYP2A6 3105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.