Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ACLY | P53396 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.49 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5641667 | 0.83 | GRIN1 (0.67) | SMN1; SMN2LMNAMAPTGRIN1ALDH1A1 | |
| SCHEMBL3461761 | 0.82 | SMN1; SMN2 (0.60) | TTRSMN1; SMN2LMNAMAPTGRIN1 | |
| SCHEMBL5646507 | 0.82 | LMNA (0.70) | SMN1; SMN2LMNAMAPTALDH1A1HPGD | |
| SCHEMBL5724332 | 0.81 | ERCC1 (0.57) | TTRSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL2912570 | 0.78 | SMN1; SMN2 (0.82) | SMN1; SMN2LMNAMAPTALDH1A1HPGD | |
| SCHEMBL29941278 | 0.76 | ERCC1 (0.59) | SMN1; SMN2GRIN1ALDH1A1HPGDGAA | |
| SCHEMBL5723707 | 0.76 | L3MBTL1 (0.51) | LMNAMAPTALDH1A1HPGDGAA | |
| SCHEMBL16641981 | 0.75 | CA12 (0.63) | LMNAMAPTALDH1A1HPGDGAA | |
| SCHEMBL5725206 | 0.75 | ERCC1 (0.57) | SMN1; SMN2MAPTGRIN1ALDH1A1HPGD | |
| SCHEMBL7195008 | 0.75 | GRM5 (0.49) | SMN1; SMN2LMNAMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-B1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LTD (GB) | 2007-09-05 | — | — | EP | disclosed |
| EP-1633715-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108676-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |