Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 14/20 | 0.38 |
| ▸ | GIPR | P48546 | 4/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212507 | 0.91 | PIK3CD (0.43) | PIK3CDMPOCYSLTR1CCNCCDK8 | |
| SCHEMBL5211464 | 0.89 | PIK3CD (0.42) | PIK3CDMPOCYSLTR1CCNCCDK8 | |
| SCHEMBL5218139 | 0.89 | PIK3CD (0.43) | PIK3CDMPOCYSLTR1CCNCCDK8 | |
| SCHEMBL5215059 | 0.88 | MPO (0.46) | PIK3CDMPOCYSLTR1CCNCCDK8 | |
| SCHEMBL5212891 | 0.85 | PIK3CD (0.47) | PIK3CDMPOCYSLTR1CCNCCDK8 | |
| SCHEMBL5215860 | 0.83 | PIK3CD (0.44) | PIK3CDMPOCYSLTR1CCNCCDK8 | |
| SCHEMBL5216343 | 0.83 | PIK3CD (0.43) | PIK3CDMPOCYSLTR1CCNCCDK8 | |
| SCHEMBL5215051 | 0.83 | PIK3CD (0.43) | PIK3CDMPOCYSLTR1CCNCCDK8 | |
| SCHEMBL5211776 | 0.76 | PIK3CD (0.45) | PIK3CDMPOCYSLTR1GCGRGIPR | |
| SCHEMBL5217976 | 0.75 | GCGR (0.37) | PIK3CDMPOCYSLTR1GCGRGIPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636213-B1 | 3-ARYLOXY AND 3-HETEROARYLOXY SUBSTITUTED BENZO(B) THIOPHENES AS THERAPEUTIC AGENTS WITH PI3K ACTIVITY | WARNER LAMBERT CO (US) | 2007-06-13 | — | — | EP | claimed |