Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GIPR | P48546 | 2/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215860 | 0.83 | PIK3CD (0.44) | GCGRMPOCYSLTR1PIK3CDPKM | |
| SCHEMBL5215051 | 0.83 | PIK3CD (0.43) | GCGRMPOCYSLTR1PIK3CDPKM | |
| SCHEMBL5211776 | 0.81 | PIK3CD (0.45) | GCGRMPOCYSLTR1PIK3CDPKM | |
| SCHEMBL5212891 | 0.81 | PIK3CD (0.47) | GCGRMPOCYSLTR1PIK3CDPKM | |
| SCHEMBL5217315 | 0.79 | PIK3CD (0.43) | MPOCYSLTR1PIK3CDPKM | |
| SCHEMBL5212507 | 0.77 | PIK3CD (0.43) | MPOCYSLTR1PIK3CDPKMGAA | |
| SCHEMBL5218139 | 0.77 | PIK3CD (0.43) | MPOCYSLTR1PIK3CDPKM | |
| SCHEMBL5211464 | 0.75 | PIK3CD (0.42) | GCGRMPOCYSLTR1PIK3CDPKM | |
| SCHEMBL5212435 | 0.75 | PIK3CD (0.42) | GCGRMPOCYSLTR1PIK3CDPKM | |
| SCHEMBL4768732 | 0.74 | ACMSD (0.40) | SMN1; SMN2MAPTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636213-B1 | 3-ARYLOXY AND 3-HETEROARYLOXY SUBSTITUTED BENZO(B) THIOPHENES AS THERAPEUTIC AGENTS WITH PI3K ACTIVITY | WARNER LAMBERT CO (US) | 2007-06-13 | — | — | EP | claimed |