Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213124 | 0.85 | HTR1F (0.56) | HTR1FALDH1A1POLBMEN1KMT2A | |
| SCHEMBL5210617 | 0.84 | HTR1F (0.66) | HTR1FNPSR1CYP2C19MEN1KMT2A | |
| SCHEMBL5210461 | 0.83 | HTR1F (0.60) | HTR1FPOLBNPSR1CYP2C19MEN1 | |
| SCHEMBL5212363 | 0.83 | TCF4 (0.59) | HTR1FALDH1A1SMN1; SMN2POLBNPSR1 | |
| Hydrochloric Acid SCHEMBL9444478 | 0.83 | KCNH2 (0.60) | HTR1FALDH1A1POLBKCNH2CYP3A4 | |
| SCHEMBL5213302 | 0.83 | HTR1F (0.65) | HTR1FNPSR1CYP2C19MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9444456 | 0.83 | KCNH2 (0.60) | HTR1FALDH1A1POLBKCNH2CYP3A4 | |
| SCHEMBL5210686 | 0.83 | HTR1F (0.53) | HTR1FALDH1A1SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL5208596 | 0.83 | HTR1F (0.53) | HTR1FALDH1A1SMN1; SMN2POLBNPSR1 | |
| SCHEMBL5210843 | 0.83 | ITGA1 (0.58) | HTR1FALDH1A1SMN1; SMN2POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153013-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1153013-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2007-10-31 | — | — | EP | disclosed |
| US-6777428-B1 | INHIBIT PEPTIDE EXTRAVASATION DUE TO STIMULATION OF THE TRIGEMINAL GANGLIA, AND ARE THEREFORE USEFUL FOR THE TREATMENT OF MIGRAINE AND ASSOCIATED DISORDERS | ELI LILLY AND COMPANY | 2004-08-17 | — | — | US | disclosed |
| CN-1149195-C | 5-HTIF agonists | — | 2004-05-12 | — | — | CN | disclosed |
| EP-1153013-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2000047559-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-08-17 | — | — | WO | disclosed |