Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089729 | 0.83 | ABCB1 (0.41) | KLK7 | |
| SCHEMBL7089731 | 0.83 | ABCB1 (0.41) | KLK7 | |
| SCHEMBL5210226 | 0.79 | ALDH1A1 (0.41) | ADORA2BKDM4EGAALMNAALDH1A1 | |
| SCHEMBL6839247 | 0.74 | ADORA2B (0.40) | ADORA2BKDM4EPOLBAPEX1ESR2 | |
| SCHEMBL6394866 | 0.74 | ADORA2B (0.40) | ADORA2BKDM4EPOLBAPEX1ESR2 | |
| SCHEMBL7818288 | 0.74 | ADORA2B (0.40) | ADORA2BKDM4EPOLBAPEX1ESR2 | |
| SCHEMBL6394870 | 0.74 | ADORA2B (0.40) | ADORA2BKDM4EPOLBAPEX1ESR2 | |
| SCHEMBL5209144 | 0.73 | KLK7 (0.31) | KLK7 | |
| SCHEMBL4189100 | 0.73 | KLK7 (0.31) | KLK7 | |
| SCHEMBL4186152 | 0.72 | KLK7 (0.31) | KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423108-B1 | C-2' METHYLATED DERIVATIVES OF PACLITAXEL FOR USE AS ANTITUMOUR AGENTS | INDENA SPA (IT) | 2007-06-06 | — | — | EP | disclosed |
| US-7153884-B2 | C-2′ methylated derivatives of paclitaxel for use as antitumour agents | INDENA S.P.A. (IT) | 2006-12-26 | — | — | US | disclosed |
| US-20040242674-A1 | C-2' methylated derivatives of paclitaxel for use as antitumour agents | INDENA S.P.A. (IT) | 2004-12-02 | — | — | US | disclosed |
| EP-1423108-A1 | C-2' METHYLATED DERIVATIVES OF PACLITAXEL FOR USE AS ANTITUMOUR AGENTS | INDENA S.p.A. (IT) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003013503-A1 | C-2' METHYLATED DERIVATIVES OF PACLITAXEL FOR USE AS ANTITUMOUR AGENTS | INDENA S.P.A. (IT) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242674-A1 | C-2' methylated derivatives of paclitaxel for use as antitumour agents | TOP2B, TOP2A, CCAR2 | ADORA2B 3277/4885KDM4E 2848/4885POLB 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.