Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | PPARG | P37231 | 4/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206559 | 0.93 | MAPT (0.46) | MAPTTP53PPARGPPARAALDH1A1 | |
| SCHEMBL2520056 | 0.90 | MAPT (0.45) | MAPTTP53PPARGPPARAALDH1A1 | |
| SCHEMBL2520058 | 0.90 | MAPT (0.45) | MAPTTP53PPARGPPARAALDH1A1 | |
| SCHEMBL5210830 | 0.88 | MAPT (0.43) | MAPTTP53 | |
| SCHEMBL5207399 | 0.88 | PPARA (0.42) | MAPTTP53PPARGPPARAALDH1A1 | |
| SCHEMBL5210445 | 0.87 | PPARA (0.48) | PPARGPPARAALDH1A1MEN1KMT2A | |
| SCHEMBL5211183 | 0.86 | ALDH1A1 (0.38) | MAPTTP53ALDH1A1MEN1KMT2A | |
| SCHEMBL2523123 | 0.83 | MAPT (0.49) | MAPTTP53PPARGPPARAALDH1A1 | |
| SCHEMBL2523125 | 0.83 | MAPT (0.49) | MAPTTP53PPARGPPARAALDH1A1 | |
| SCHEMBL5299157 | 0.83 | MAPT (0.44) | MAPTTP53PPARGPPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448523-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | NOVARTIS AG (CH) | 2007-08-22 | — | — | EP | claimed |